01 - Pat chicken breasts dry with paper towels and season both sides generously with 1 teaspoon salt and 1/2 teaspoon black pepper.
02 - In a large bowl, whisk together buttermilk, hot sauce, chopped jalapeños, and minced garlic until well combined.
03 - Add seasoned chicken breasts to the marinade, ensuring they are fully submerged. Cover and refrigerate for at least 1 hour, up to overnight for maximum flavor penetration.
04 - In a shallow dish, combine flour, cornmeal, smoked paprika, cayenne pepper, garlic powder, onion powder, salt, and pepper. Mix thoroughly to distribute spices evenly.
05 - Remove chicken from marinade, allowing excess to drip off. Press each piece firmly into breading mixture, coating completely. Shake off excess and place on wire rack.
06 - Pour about 2 inches of vegetable oil into deep skillet or Dutch oven. Heat to 350°F, maintaining temperature throughout frying process.
07 - Fry chicken breasts in batches, cooking 6–8 minutes per side until golden brown and internal temperature reaches 165°F. Do not overcrowd the pan.
08 - Transfer cooked chicken to wire rack or paper towels to drain. Let rest 5 minutes before serving to retain juices.